Before using any of the clipboard operations such as Cut, Copy, or Paste, a selection must be made on the file (see Using the Clipboard). Selections can be made with either the mouse, the keyboard, or through the Select Range dialog box.

To select bytes with the mouse, click a file with the left mouse button and drag the mouse over the file. To select bytes with the keyboard, hold down the Shift key and move the cursor with any of the cursor movement keys (see Using the Hex Editor for a list of keys). The bytes that are selected will be displayed with a blue background. The number of bytes selected and the start address of the selection are displayed in the Status Bar along the bottom of the application.

All bytes in the file can be selected at once using the 'Edit > Select All' menu option.

Bytes can also be selected with the Select Range dialog box (see Selecting a Range). The start address and number of bytes of the selection can be viewed at any time by opening the Select Range dialog box.